ea0011p462 | Endocrine tumours and neoplasia | ECE2006
Zatelli MC
, Luchin A
, pICCIN D
, Tagliati F
, Bottoni A
, Vignali C
, Bondanelli M
, degli Uberti EC
Medullary thyroid carcinoma (MTC) is a malignant tumour deriving from parafollicular C cells, with a highly chemoresistant phenotype. Failure of medical therapy has been ascribed, at least in part, to multi drug resistance (MDR1) gene over-expression. MDR1 encodes for a transmembrane glycoprotein, P-gp, which hampers intracellular accumulation of cytotoxic drugs. It has been demonstrated that P-gp expression and function depend on cyclo-oxygenase 2 (COX-2) expression, which is...